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Male Impotence Treatment Information



Male Impotence Treatment Information

Until recently, if you sought medical treatment for impotence were told "It's all in your head".  Doctors labeled you with a psychological disorder and they were referred to counseling.  Today, there are many treatment options available, the treatment option you choose should be specific and responsive to your needs and expectations as well as your partners. 

The following is a summary of various treatment options available today:

Oral Medications -currently the two most popular medications for the treatment of impotence are the following:

Cialis represents a new class of medications known as PDE-5 inhibitors. These medications are used to treat impotence. Cialis has been approved by the  European Commission for the treatment of Impotence and is expected to be in pharmacies by spring of 2003.

In technical terms Cialis exerts its action by effecting two enzymes, Cyclic guanosine monophosphate (cGMP) and phosphodiesterase type 5 (PDE5)  that play important roles in erectile function. Sexual stimulation triggers the local release of nitric oxide (NO) from nerves and endothelial cells in the penis. NO stimulates an enzyme that catalyzes formation of cGMP from the nucleotide guanosine 5-triphospate (GTP) in the penile blood vessels and corpus cavernosum walls.

The cGMP causes vasodilation of arteries, allowing the influx of blood into the corpus cavernosum. Increased blood flow into the penis causes the erectile tissue to expand. When the erectile tissue has expanded sufficiently, the veins draining the corpus cavernosum become compressed. This decreases the outflow of blood from the penis, and the blood remains in the corpus cavernosum to keep the penis erect.

The enzyme PDE5 eventually causes degradation of the cGMP, and the erection ends. Please refer to the following diagram (click here for details):

Cialis represents the longest acting male impotence treatment medciation.

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Viagra (sildenafil citrate) has change the course of treatment for Impotence. Viagra is dispensed as a pill and ingested orally.  Approximately 30-60 minutes later the drug is absorbed in the bloodstream. 


The physiologic mechanism of erection of the penis involves release of nitric oxide (NO) in the corpus cavernosum duringsexual stimulation. NO then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (cGMP), producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood. Viagra has no direct relaxant effect on isolated human corpus cavernosum, but enhances the effect of nitric oxide (NO) by inhibiting phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum. When sexual stimulation causes local release of NO, inhibition of PDE5 by sildenafil causes increased levels of cGMP in the corpus cavernosum, resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum.

Viagra represents the most prescribed impotence treatment medication. An estimated six Viagra tablets are prescribed by doctors worldwide each second.

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Herbal Approaches - have become very popular as an initial treatment for Impotence. Herbal supplements for the treatment Impotence should contain a combination of the following ingredients: Yohimbe (bark), Maca (root), Horny Goat Weed (leaf), Saw Palmetto (berry), Schizandra (berry), Guarana (seed) Tribulus Terrestris (aerial part), Ashwagandha (root), Asparagus Racemosus (aerial part), Ginger (root) Cayenne Pepper (berry), L Tyrosine, and L Histidine. Physicians' Select Male Libido Enhancement capsules provide the most
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Penile Injection Therapy
uses a hypodermic needle to inject medication (mixture of papaverine, phentolamine and prostoglandin) into the side of the penis. The medication relaxes the smooth muscle tissue of the penis allowing for an erection.  These injections can be painful, result in scare tissue formation at the injection site and cause priapism (prolonged and painful engorgement of the penis). The product is available through Pharmacia and Upjohn (Caverjet) and Scharz Pharma, Inc (EDEX) at approximately $18.00 per dose.




Urethral Inserts
consists of a disposable applicator, small enough to fit into the urethra.  The applicator is inserted into the urethra approximately one inch and the medication (prostaglandin E-1) is released.  As a result, an erection occurs lasting 30-60 minutes.  Patient acceptance is still an issue secondary to expense and the low success rate as compared to other treatments for Impotence. The inserts are available through the pharmaceutical company Vivus Inc.



Vacuum Therapy
works by placing a cylinder with an attached pump over the penis.  The pump creates a vacuum in the cylinder, which pulls blood into the penis to create an erection.  The cylinder is then removed while simultaneously a constriction band is placed at the base of the penis.  This will usually keep the penis erect for up to thirty minutes, These devices range from $150.00-400.00 and can be purchased through Mentor Urology, POST-T-VAC, Inc., American Med Tech, Inc.


Hormonal Therapy is used to treat the small percentage of individuals who have abnormally low levels of testosterone. During the initial consultation a physician will likely order hormone tests (LH and Prolactin) first to exclude other causes of low testosterone levels.  If appropriate, testosterone is available in a transdermal adhesive patch.  The patch is available through Androderm (SmithKline Beecham) and Testroderm (Alza Pharmaceuticals), at a cost of $20.00 per patch.


Vascular Surgery may involve both the arterial and venous systems.  Venous ligation has been reported to be effective in patients with venous leakage.  However, it is often difficult to diagnose individuals with this condition given are current testing capabilities; therefore, it is difficult to predict their outcome prior to surgery.  Arterial re-vasculation procedures are limited to congenital or traumatic vascular abnormalities.  Similar to venous testing, complete standardization diagnostic testing has not been established, so difficulties persists in predicting surgical results.

 

Penile Implants requires surgical insertion of a prosthetic device.  Three forms of penile prosthesis are currently available flexible, malleable and inflatable. Flexible or Malleable rods consist of two semi-rigid, flexible rods which make the penis firm enough for intercourse.  There are also inflatable prosthetic devices that produce a more natural erection.  When an erection is desired the pump (located in the scrotum) is squeezed, this in turn inflates a cylinder creating an erection.  Following intercourse, the pump is released and the penis returns too normal.  These devices have been associated with postoperative infections, mechanical failure, silicon particle shedding and the risk of the initial surgery.  These prosthetics are available through American Medical Systems and Mentor Urology.


Psychotherapy and/or Behavioral Therapy
have been found to be beneficial in treating Impotence.  Although the majority of causes of Impotence are physical, there are quite frequently underlying psychosocial factors involved as well.  Psychotherapy and/or behavioral therapy may be helpful in individuals whom no organic cause for Impotence has been detected.  Therapy often focuses on complications surrounding performance anxiety, dysfunctional relationships, loss of a partner, psychotic disorders, substance abuse, etc.


Male Impotence Treatment Conclusions

Cialis and Viagra remain the most recommended male impotence treatments by doctors, worldwide. While Viagra remains the most popular male impotence treatment. Cialis is without question the longest acting impotence treatment. Men report enhanced erections for some 36 hours following a single dose of the impotence treatment drug.

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